The Significance of Excepient...a Review

Authors

  • Sujata Laxman Ramteke ADAMC ,college , Ashta Sangli

Abstract

Significance of Excipients………A Review

 

Vd. Sujata Ramteke (PG scholar), Guide Vd. Avinash Chougule, HOD – Vd. Mahesh Inamdar, Department of Ras-shastra & Bhaishajya Kalpana, Shri Annasaheb Dange Ayurvedic Medical College, Ashta, (Dist) Sangli

 

 

Abstract

An excipient is a non-therapeutic substance and active ingredients which are essentially included in the development and designing of drug products. It is used for bulking up solid formulations and long-term stabilization. Excipient plays an important role in formulation that decide dosage form as well as Pharmacokinetics and pharmacodynamics of medicine. It also improves dissolution rate and bioavailability of the drug and also improve bulkiness, disintegration. Excipients can initiate, participate or propagate in chemical or physical interactions with drug compounds. Excipients as like other active pharmaceutical ingredients also need to be standardize and stabilize. Specific excipients are best suited for a particular dosage form so proper selection of the excipients is very much important as various interactions take place during its course of stay in formulation.

 

Keywords: Excipient, Formulation, bioavailability, pharmaceutical ingredients.

Downloads

Download data is not yet available.

References

References: -
1. Anonymous: WHO Expert Committee on Specifications for Pharmaceutical Preparations.
Fortieth report, Geneva: World Health Organization; 2006. WHO Technical Report Series No-
937:183.

2. Pifferi G and Restani P: The safety of pharmaceutical excipients. Il Farmaco 2003; 58:541-50.

3. Pifferi G and Restani P: The safety of pharmaceutical excipients. IL Farmaco 2003; 58: 541-
50.

4 . Anonymous: Good manufacturing practices: supplementary guidelines for the manufacture
of pharmaceutical excipients. WHO Expert Committee on Specifications for Pharmaceutical
Preparations. Thirty-fifth report.Geneva: World Health Organization; 1999: Annex 5 (WHO
Technical Report Series, No. 885).

5 .Apte S P and Ugwu S O: A review and classification of Emerging excipients in parenteral
medications. Pharmaceutical Technology 2003; 27:46.
6. Sharma PV: Dravyaguna Vijanana Vol-1. Choukhambha Bharati academy Varanasi, 2006.
7. Charak: Charak Samhita Sutrasthana 1/24.
8. Charak: Charak Samhita Sutrasthana 9/3.
9. Anthony Cerulli: Somatic Lessons: Narrating Patient-hood and Illness in Indian Medical
Literature. SUNY Press 2011. p. 37.

10. Patel S, Agrawal S and Singh L B: Natural Binding Agents in Tablet Formulation. Int J Pharm
& Bio Archives 2012; 3:466-73.

11. ThakurM, Porwal P, Pal P, Shukla K and Mahajan S C: Development of standardization of
trikatu churna: A spectrophotometric approach. Int J of Pharm & Life Sci 2012; 3: 2254-58.

12. Atal CK, Dubey RK and Singh J: Biochemical basis of enhanced drug bioavailability by
piperine: evidence that piperine is a potent inhibitor of drug metabolism. J Pharmacol Exp
Ther 1985; 232: 258-62.

13. Sreelal A M, Basavaraj G and Reshma S M: Critical analysis on pharmaceutics of alcoholic
preparations (asava-arishta) in Ayurveda. JAHM 2013; 1:15.


14. Krishnamachary B, Purushothaman A K, Pemiah B, Krishnaswamy S, Krishnan UM,
Sethuraman S and Sekar RK: Bhanupaka: A Green Process in the Preparation of an Indian
Ayurvedic Medicine, Lauha Bhasma. Journal of Chemistry 2013, Article ID 951951.

15. Prakash B: Use of Metal in Ayurvedic Medicine. Indian J of History of science 1997; 32: 1-
28.

16. Shirwaikar A, Shirwaikar A, Prabhu SL and Kumar GA: Herbal Excipients in Novel Drug Delivery
System.Indian J Pharm Sci 2008; 70: 415-22.

17. Satturwar PM, Fulzele SV and Dorle AK: Biodegradation and in vivo biocompatibility of rosin: A
natural film- forming polymer. AAPS Pharm Sci Tech 2003; 4: 1-6.

18. Sharangdhar: Sharangdhar Samhita, Brahmanand Tripathi, Choukhambha Surbharati Prakasan,
ed.2010, Madhyamkhand 1/6.

19. Singh N and Chaudhary A: A comparative review study of Sneha Kalpana (Paka) vis-a-vis
liposome. AYU 2011; 32: 103 - 08.

20. Chaudhary A, Singh N, Dalvi M and Wele A: Progressive review of Sandhana kalpana (biomedical
fermentation): an advanced innovative dosage form of Ayurveda. AYU 2011; 32: 408–17.

21. Venkatarajua M P, Gowdaa D V, Rajeshb K S and Shivakumara H G:Xanthan and locust bean gum
(from Ceratoniasiliqua) matrix tablets for oral controlled delivery of propranolol hydrochloride.
Asian Journal of Pharmaceutical Sciences 2007; 2: 239-48.

22. Drabu S, Khatri S, Babu S and Lohani P: Use of Herbal Bioenhancers to Increase the Bioavailability
of Drugs. RJPBCS 2011; 2: 111.

23. Principle of Drug Action: [Access on 15/09/2015]. Available from:
http://www.ccras.nic.in/ayurveda/ Chapter-4%20 Drugs. pdf.

24. Moribe K, Limwikrant W, Higashi K and Yamamoto K: Drug Nanoparticle Formulation Using
Ascorbic Acid Derivatives. Journal of Drug Delivery Volume 2011; Article ID 138929: 1-9.

25. Baldrick P: Pharmaceutical excipient development: the need for clinical guidance. Regul Toxicol
Pharmacol 2000; 32: 210.

26. Singh A, Tandon S, Sand NK. (2014) Active Ingredient Estimation of Clopyralid Formulation by
Reversed Phase HPLC. J Chromatogr Sep Tech 6:257.

27. Trivedi MK, Nayak G, Patil S, Tallapragada RM, Mishra R (2015) Influence of Biofield Treatment
on Physicochemical Properties of Hydroxyethyl Cellulose and Hydroxypropyl Cellulose. J Mol
Pharm Org Process Res 3: 126.

28. Jain R, Sukla SK, Nema N, Panday A (2015) Drug Nano-particle: A Release Kinetics. J Nanomed
Nanotechnol 6:317. doi:10.4172/2157-7439.

29. Chauhan MK, Bhatt N (2015) A Simple and Modified Method Development of Vancomycin Using
High Performance Liquid Chromatography. J Chromatogr Sep Tech 6:296.

30. Mohd AB, Vemula SK (2016) Formulation and Pharmacokinetics of Vitamin E TPGS Melt
Dispersion Granules: An Approach to Improve Oral Delivery of Flurbiprofen. J Bioequiv Availab
8:089-94.

31. Mukthinuthalapati MA, Bukkapatnam V (2015) A Novel Validated Stability- Indicating RP-HPLC
Method for the Determination of Exemestane (Steroidal Aromatase Inhibitor). J Bioequiv Availab 7:288-292. doi:10.4172/jbb.1000256

32. Jana S, Trivedi MK, Tallapragada RM, Branton A, Trivedi D, Nayak G, et al. (2015)
Characterization of Physicochemical and Thermal Properties of Chitosan and Sodium Alginate
after Biofield Treatment. Pharm Anal Acta 6:430.

33. Patel P, Patel P, Giram P (2015) Bioanalytical Method Development and Validation for
Latanoprost Quantification in Pharmaceutical Opthalmic Microemulsion Formulation by RP-
HPLC. J Anal Bioanal Tech 6:284.

34. Trivedi MK, Tallapragada RM, Branton A, Trivedi D, Nayak G, et al. (2015) Characterization of
Physical, Thermal and Spectral Properties of Biofield Treated 2, 6-Diaminopyridine. J Develop
Drugs

35. Trivedi MK, Tallapragada RM, Branton A, Trivedi D, Nayak G, et al. (2015) Physical, Thermal
and Spectral Properties of Biofield Energy Treated 2,4-Dihydroxybenzophenone. Clin Pharmacol
Biopharm 4:145.

37. Enose AA, Dasan P, Sivaramakrishanan H, Kakkar V (2016) Formulation, Characterization and
Pharmacokinetic Evaluation of Telmisartan Solid Dispersions. J Mol Pharm Org Process Res
4:131.

39. Maroof K, Zafar F, Ali H, Naveed S, Tanwir S (2016) Scope of Nanotechnology in Drug Delivery.
J Bioequiv Availab 8:001-005.

40. Mohd AB, Vemula SK (2016) Formulation and Pharmacokinetics of Vitamin E TPGS Melt
Dispersion Granules: An Approach to Improve Oral Delivery of Flurbiprofen. J Bioequiv Availab
8:089-94.

41. Krishnaiah YSR (2010) Pharmaceutical Technologies for Enhancing Oral Bioavailability of Poorly
Soluble Drugs. J Bioequiv Availab 2: 028-036.

42. Abdul Althaf S, Sailaja PB, Ashwin Kumar M (2012) Formulation, Evaluation and Mathematical
Modelling of Clopidogrel Bisulphate & Aspirin Immediate Release Bilayer Tablets. Pharmaceut
Anal Acta 3:194.

43. Hart ML, Do DP, Ansari RA, Rizvi SAA (2013) Brief Overview of Various Approaches to Enhance
Drug Solubility. J Develop Drugs 2: 115.

44. Jethara SI, Patel MR (2015) Enhanced Solubility and Dissolution Rate of Aceclofenac by Using
Spray Drying Techniques. Intel Prop Rights 3:140.

45. Cavallari C, Fini A, Pérez-Artacho Santos B (2013) Thermal Study of Anhydrous and Hydrated
Forms of Olanzapine. Pharm Anal Acta 4:237.

46. Ertekin B, Çimen Z, Yilmaz H, Yilmaz UT (2016) Synthesis and Characterization of
Polyaniline/Ignimbrite Nano-Composite Material. J Material Sci Eng 5: 237.

47. Samanta A, Bandyopadhyay B, Das N (2016) Formulation of Catechin Hydrate Nanocapsule and
Study of its Bioavailability. Med chem (Los Angeles) 6:399-404.

49. Herman Ermens, A report of IPEC,Pharmaceutical Excipients – The Past and Future, Business
Briefing. Pharmagenerics,2004.

50. Baldrick P. Pharmaceutical excipient development: the need for clinical guidance, Regul Toxicol
Pharmacol, 2000; 32: 210

Published

2018-08-07

How to Cite

Ramteke, S. L. (2018). The Significance of Excepient.a Review. Ayurline: International Journal of Research in Indian Medicine, 2(5th). Retrieved from https://ayurline.in/index.php/ayurline/article/view/136