Bird’s eye view on bhrungraj (eclipta alba hassk.)
Article pdf download
Publication Certificate


Bhrungraj, phytochemistry, Ayurvedic formulations

How to Cite

Tathe, M. (2019). Bird’s eye view on bhrungraj (eclipta alba hassk.). Ayurline: IJ-RIM, 3(05). Retrieved from


Ayurveda plays an important role for healthy and disease free life. Medicinal plants can be best option for pharma-industries to discover new chemical compound from it. Here, we took Bhrungraj commonly known as ‘false daisy’ well known medicinal plant, species of the plant from family Asteraceae for review purpose. In this review article we are going to focus morphology, phytochemistry, ethno-pharmacology, phytochemical constituents, clinical studies and last but not the least Ayurvedic aspects of Bhrungraj. Bhrungraj is reviewed through all angles from origin and morphology up to recent research works. Ayurveda explains its different actions and modern science proves the different pharmacological activities of it. Here, we put in front of you that how medicinal plant can be used by modern science as well as ayurveda. Each part of Bhrungraj is traditionally used for many diseased conditions for different communities. In ayurveda it is mainly used for hair problems. It is used as a valuable medicinal plant particularly for the treatment of liver disorders, gastro-intestinal disorders, respiratory tract disorders and hair problems. A modern science proves its different pharmacological activities by using its different extracts. Various phytochemical constituents have been isolated and identified which includes wedelolactone, eclalbasaponin, urosolic acid, luteolin and apigenin. Recently performed scientific researches show that above components can form the next generation to treat cancer, liver diseases, skin and hair problem.

Article pdf download
Publication Certificate


1. Chatterjee S.K. 2002. Medicinal plants in India with relation to harvesting management
2. H.C. Laxman, Tanzima Yeasmin, Gabriel K.P. (2014) Herbs of Asteraceae and their ethno-medicinal uses in dermatological problems. 127-129.
3. Sharma, P. C., Yelne, M. B. and Denn’s,T. J., Database on medicinal plants used in Ayurveda, Vol-2, (Central council for research in Ayurved and Siddha , New Delhi,2001 ), 112
4. The Ayurvedic Pharmacopoeia of India, Part-I, 1st Edition,Vol-II, ( The controller of publications n civil lines, Delhi), 21-22.
5. N. M. Mithun, S. Shashidhara, and R. Vivek Kumar, “Eclipta alba (L.) A review on its phytochemical and pharmacological profile,” Pharmacologyonline, vol. 1, pp. 345–357, 2011.
6. Devireddy Anand, Saravanan periyasamy (2014), “Phytochemical Analysis of Leaf Extract of Eclipta Alba (L.) Hassk. by GC-MS Method” IJPPR; Vol. 6; Issue 3; 562-566.
7. M. Zhang, Y. Y. Chen, X. H. Di, and M. Liu, “Isolation and identification of ecliptasaponin D from Eclipta alba (L.) hassk,” Yao Xue Xue Bao, vol. 32, no. 8, pp. 633–634, 1997.
8. M. Zhang and Y. Chen (1996), “Chemical constituents of Eclipta alba (L.) Hassk,” Zhongguo Zhong Yao Za Zhi, vol. 21, no. 8, pp. 480– 510,.
9. Wagner A, Geyer H, Kiso B, Hikino Y and Rao GS, Coumestans as the Main Active Principles of the Liver drugs Eclipta alba and Wedelia calendulacea, Planta Med. ,Vol-52, 1986, 370-374.
10. Kaushik-Basu, N., Bopda-Waffo, A., Talele, T. T., Basu, A., Costa, P. R. R., da Silva, A. J. M., … Noel, F. (2008). Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors. Nucleic Acids Research, 36(5), 1482–1496.doi:10.1093/nar/gkm1178
11. Prakash, T.; Rao, N. R.; Swamy, A. H. (2008). "Neuropharmacological studies on Wedelia calendulacea Less stem extract". Phytomedicine. 15 (11): 959–70. doi:10.101 6/j.phymed.2008.05.005. PMID 18603418.
12. Dinesh Manvar, Mahesh Mishra, Surinder Kumar, Virendra N. Pandey , “ Identification and evaluation of anti Hepatitis C virus phytochemicals from Eclipta alba” Journal of Ethnopharmacology 144 (2012) 545-554.
13. Purushothaman Balakrishnan, Gowtham kumar Sekar, Prasanna srinivasan Ramalingam, Kumaran Shanmugam (2018) , “ Distinctive Pharmacological Activities of Eclipta alba and it’s Coumestan Wedelolactone” IAJPS; 05(04); 2996-3002.
14. Uzma Shahab, Mohammad Faisal, Abdulrahman A. Altar, Saheem Ahmad , “Impact of wedelolactone in the anti-glycation and anti-diabetic activity in experimental diabetic animals” International Union of Biochemistry and Molecular Biology Life, 2018, Jun;70(6):547-552.
15. K.P.Mansoorali, T . Prakash, D. Kotresha, K. Prabhu, N. Rama Rao(2012), “ Cerebroprotective Effect of Eclipta alba against global model of cerebral ischemia induced oxidative stress in rats” Phytomedicine 19 1108-1116.
16. Sivlokanathan Sarveshwaran , Subhash C. Gautam and Jagadananada Gosh Wedelolactone, “a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt” International Journal of Oncology 2012, 41: 2191-2199.
17. B.P.S. Sagar, Rajiv Panwar, Ashwini Goswami, Kuldeep Kadian, Kanchan Tyagi, Manoj Chugh, Sunita Dalal & R. Zafar (2006) Pharmacokinetic Interactions of Antihepatotoxic Wedelolactone with Paracetamol in Wistar Albino Rats, Pharmaceutical Biology, 44:7, 554-561, DOI: 10.1080/13880200600885242
18. Nehybova T, Smarda J, Daniel L, Brezovsky J, Benes P., “ Wedelolactone induces growth of breast cancer cells by stimulation of estrogen receptor signaling”. The journal of steroid biochemistry and molecular boiology 2015, vol. 152, 76-83
19. Lu y, Hu D, Ma S, Zhao X, Wang S, Wei G, Wang X, Wen A, Wang J, “Protective effect of wedelolactone against CCl4-induced acute liver injury in mice.” International Immunopharmacol. 2016 May; 34:44-52. doi: 10.1016/j.intimp.2016.02.003. Epub 2016 Feb 24.
20. Shen P, Yang X, Jiang J, Wang X, Liang T, He L, “Wedelolactone from Eclipta alba inhibits lipopolysaccharide-enhanced cell proliferation of human renal mesangial cells via NF-κB signaling pathway” Am J Transl Res. 2017 May 15; 9(5): 2132-2142.
21. XicanLi, TingtingWang , JingjingLiu, YulongLiu, JunZhang , JianLin ,ZhongxiangZhao, DongfengChen, “Effect and mechanism of wedelolactone as antioxidant-coumestan on OH-treated mesenchymal stem cells” Arabian journal of chemistry.
22. K.P. Unnikrishnan, Anu Fathima, K.M. Hashim and Indira Balachandran, 2007. Antioxidant Studies and Determination of Wedelolactone in Eclipta alba . Journal of Plant Sciences, 2: 459-464.
23. Samiulla D. Syed, Mundkinajeddu Deepak , Shivanna Yogisha , Arun P. Chandrashekar , Keerthi , A. Muddarachappa, Prashanth D'Souza , Amit Agarwal , B. V. Venkataraman, “ Trypsin inhibitory effect of wedelolactone and demethylwedelolactone” phytothetapy research: 17(4); p.420-421
24. Lee Y.-J., Lin W.-L., Chen N.-F., Chuang S.-K., Tseng T.-H., “Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice” (2012) European Journal of Medicinal Chemistry, 56 , pp. 361-367.
25. Liu, Y.-Q., Hong, Z.-L., Zhan, L.-B., Chu, H.-Y., Zhang, X.-Z., & Li, G.-H. (2016). Wedelolactone enhances osteoblastogenesis by regulating Wnt/β-catenin signaling pathway but suppresses osteoclastogenesis by NF-κB/c-fos/NFATc1 pathway. Scientific Reports, 6(1).doi:10.1038/srep32260
26. Ali, F., Khan, B. A., & Sultana, S. (2016). Wedelolactone mitigates UVB induced oxidative stress, inflammation and early tumor promotion events in murine skin: plausible role of NFkB pathway. European Journal of Pharmacology, 786, 253–264.doi:10.1016/j.ejphar.2016.05.008
27. Diogo, L. C., Fernandes, R. S., Marcussi, S., Menaldo, D. L., Roberto, P. G., Matrangulo, P. V. F., … Lourenço, M. V. (2009). Inhibition of Snake Venoms and Phospholipases A2by Extracts from Native and Genetically Modified Eclipta alba: Isolation of Active Coumestans. Basic & Clinical Pharmacology & Toxicology, 104(4), 293–299. doi:10.1111/j.1742-7843.2008.00350.
28. Muke S, Kaikini A, Peshattiwar V, Bagle S, Dighe V and Sathaye S (2018) Neuroprotective Effect of Coumarin Nasal Formulation: Kindling Model Assessment of Epilepsy. Front. Pharmacol. 9:992. doi: 10.3389/fphar.2018.0099.
29. Dalal, Sunita; Kataria, Sudhir K.; Sastry, K. V.; and Rana, SVS (2010) "Phytochemical Screening of Methanolic Extract and Antibacterial Activity of Active Principles of Hepatoprotective Herb, Eclipta alba," Ethnobotanical Leaflets: Vol. 2010 : Iss. 3 , Article 3.
30. Mendes, F. N., Morais, S. M., Vasconcelos Silva, M., Vieira, I., Rodrigues, P. A., BelizÁriodinizD. and Pinto Vieira Ícaro (1) “DETERMINATION OF WEDELOLACTONE AND DEMETHYLWEDELOLACTONE IN ECLIPTA ALBA (L) HASSK BY HPLC”, International Journal of Pharmacy and Pharmaceutical Sciences, 6(10), pp. 403-406. Available at: (Accessed: 6March2019).
31. Liu, C., Li, Y., Zuo, G., Xu, W., Gao, H., Yang, Y., … Li, Y. (2013). Oleanolic Acid Diminishes Liquid Fructose-Induced Fatty Liver in Rats: Role of Modulation of Hepatic Sterol Regulatory Element-Binding Protein-1c-Mediated Expression of Genes Responsible for De Novo Fatty Acid Synthesis. Evidence-Based Complementary and Alternative Medicine, 2013, 1–11.doi:10.1155/2013/534084
32. Nyakudya, T. T., Mukwevho, E., & Erlwanger, K. H. (2018). The protective effect of neonatal oral administration of oleanolic acid against the subsequent development of fructose-induced metabolic dysfunction in male and female rats. Nutrition & Metabolism, 15(1). doi:10.1186/s12986-018-0314-7
33. Yahara, S., Ding, N., Nohara, T., Masuda, K., & Ageta, H. (1997). Taraxastane glycosides from Eclipta alba. Phytochemistry, 44(1), 131–135. doi:10.1016/s0031-9422(96)00473-6
34. Shoji Yahara, Ning Ding, Toshihiro Nohara.( 1994), “Oleanane Glycosides from Eclipta alba”, 42 (6) 1336-1338
35. Bhattacharjee A., Chakraborty A., Dutta D., Mukhopadhay G. (2017) “ Standardization of Eclipta alba by HPTLC, HPLC and AAS”. Pharm Anal Acta, 8:541
36. Roy, R.K., Thakur, M. & Dixit, V.K. Arch Dermatol Res (2008), “Hair growth promoting activity of Eclipta alba in male albino rats 300: 357-364.
37. Abdel-Kader, M. S., Bahler, B. D., Malone, S., Werkhoven, M. C. M., van Troon, F., David, … Kingston, D. G. I. (1998). DNA-Damaging Steroidal Alkaloids from Eclipta alba from the Suriname Rainforest1. Journal of Natural Products, 61(10), 1202–1208.doi:10.1021/np970561c
38. Tambe, R., Patil, A., Jain, P., Sancheti, J., Somani, G., & Sathaye, S. (2016). Assessment of luteolin isolated from Eclipta alba leaves in animal models of epilepsy. Pharmaceutical Biology, 55(1), 264–268.doi:10.1080/13880209.2016.1260597
39. Cheruvu, H. S., Yadav, N. K., Valicherla, G. R., Arya, R. K., Hussain, Z., Sharma, C., … Gayen, J. R. (2018). LC-MS/MS method for the simultaneous quantification of luteolin, wedelolactone and apigenin in mice plasma using hansen solubility parameters for liquid-liquid extraction: Application to pharmacokinetics of Eclipta alba chloroform fraction. Journal of Chromatography B, 1081-1082, 76–86.doi:10.1016/j.jchromb.2018.01.035
40. Picman, A. K. (1986). Biological activities of sesquiterpene lactones. Biochemical Systematics and Ecology, 14(3), 255–281.doi:10.1016/0305-1978(86)90101-8
41. Das B. Chakravarty.A. K., “Ecliptal a new terthienyl aldehyde from eclipta alba” Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 30(11): 1052-1053
42. Abhishek Gupta, Ashok Kumar, Durgesh Kumar, Rohit Singh, Kripa Shankar, Salil Varshney, Sujith Rajan, Ankita Srivastava, Sanchita Gupta, T.Narender, Anil Nilkanth Gaikwad, (2018), “Ecliptal, a promising natural lead isolated from Eclipta alba modulates adipocyte function and ameliorates metabolic syndrome” ; Toxicology and Applied Pharmacology; 338: 134-147.
43. R. K. Upadhyay, M. B. Pandey, R. N. Jha &V. B. Pandey, “Eclalbatin, a Triterpene Saponin from Eclipta Alba”, Journal of Asian Natural Products Research, 3:3, 213-217,
44. A. Gautam and A. Batra (2012), “Ethnomedicinal plant product used by the local traditional practitioners in Mount Abu,” World Journal of Pharmaceutical Sciences, vol. 1, no. 1, pp. 10–18.
45. K. Hussain, M. F. Nisar, A. Majeed, K. Nawaz, and K. H. Bhatti,( 2010) “Ethnomedicinal survey for important plants of Jalalpur Jattan, District Gujrat, Punjab, Pakistan,” Ethnobotanical Leaflets, vol. 14, pp. 807–825.
46. M. Rahmatullah, M. A. H. Mollik, A. T. M. A. Azam 2009), “Ethnobotanical survey of the Santal tribe residing in Thakurgaon District, Bangladesh,” American-Eurasian Journal of Sustainable Agriculture, vol. 3, no. 4, pp. 889–898.
47. W. Ahmad, A. Hasan, I. Ahmad, and F. Zeenat,( 2011) “Ethnomedicinal plants of Mansoora, Malegaon,” Hamdard Medicus, vol. 54,pp. 29–40.
48. S. Das, M. D. Choudhury, S. C. Mandal, and A. D. Talukdar(2012),“Traditional knowledge of ethnomedicinal Hepatoprotective plants used by certain ethnic communities of Tripura State,” Indian Journal of Fundamental and Applied Life Sciences, vol. 2, pp. 84–97,
49. B. B. S. Kapoor and M. Sharma, (2013) “Ethnomedicinal aspects of some medicinal plants of Hanumangarh District of Rajasthan,” Journal of Pharmaceutical and Biological Sciences, vol. 1, pp. 7–9
50. A. Sharma, M. S. Sharma, A. Mishra, S. Sharma, B. Kumar, and A. Bhandari (2011), “A review on Thar plants used in liver diseases,” International Journal of Research in Pharmacy and Chemistry, vol. 1, pp. 224–236.
51. V. Kumar and P. K. Singh (2014), “Ethnomedicinal plants used as antidote for snake-bite and scorpion-sting in Bundelkhand (U.P.), India,” IOSR Journal of Environmental Science, Toxicologyand Food Technology, vol. 8, no. 1, pp. 52–55.
52. D. F. Malan and D. F. R. Neuba(2011), “Traditional practices and medicinal plants use during pregnancy by Anyi-Ndenyewomen (Eastern Cˆote d’Ivoire),” African Journal of Reproductive Health,vol. 15, no. 1, pp. 85–93.
53. L. J. Landge and A. T. Kalse (2014), “Indigenous herbal medicines used by tribal people in Satpuda Mountai,” International Scientific Journal, vol. 1, pp. 65–69.
54. B. L. Bhellum and S. Singh(2012), “Ethnomedicinal plants of district Samba of Jammu and Kashmir State (List-II),” International Journal of Scientific and Research Publications, vol. 2, pp. 1–8.
55. M. F. Nisar, S. Ismail, M. Arshad, A. Majeed, and M. Arfan (2011), “Ethnomedicinal flora of District Mandi Bahauddin, Pakistan,”Middle-East Journal of Scientific Research, vol. 9, pp. 233–238.
56. A. Kumar, S. Agarwal, A. Singh, and D. Deepak (2012), “Medicobotanical study of some weeds growing in Moradabad District of Western Uttar Pradesh in India,” Indian Journal of Scientific Research, vol. 3, pp. 107–111.
57. N. R. Chakraborty and B. Duary (2014), “Utilization of some weeds as medicine by the local people in Birbhum District of West Bengal, India,” International Journal of Bio-resource and Stress Management, vol. 5, pp. 148–152.
58. M. Panghal, V. Arya, S. Yadav, S. Kumar, and J. P. Yadav (2010),“Indigenous knowledge of medicinal plants used by Saperas community of Khetawas, Jhajjar District, Haryana, India,” Journal of Ethnobiology and Ethnomedicine, vol. 6, article 4.
59. Muhammad Shabeer, Gul Abad Khan, Akhtar Ali, Zakir Ullah and Fazl-i-Sattar, 2011 “Standardization of Eclipta alba (L)” Asian J. Research Chem. 4(12)pp-1825-1828.
60. Yadav Pramod, Harisha CR, Prajapati PK, (2011), “Validation of pharmacopoeial characters of Bhringaraja (Eclipta alba Linn. Hassk.) Journal of Current Pharmaceutical Research;8 (1): 17-24
61. Seetharam YN. Venugopal RB. Pharmacognostic Studies on Eclipta alba Hassk. Aryavaidyan, 2000;13(2):45-49.
62. Tanu Sharma, M.C. Sidhu.(2017), “ Cytomorphological and Preliminary Phytochemical Screening of Eclipta alba (L.) Hassk.” International Journal of Green Pharmacy; 11(1): S23.
63. Leal, L. K. A. ., Ferreira, A. A. ., Bezerra, G. ., Matos, F. J. ., & Viana, G. S. . (2000). Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. Journal of Ethnopharmacology, 70(2), 151–159. doi:10.1016/s0378-8741(99)00165-8
64. Zainab A. Shanshol, Mouruj A. Alaubydi, Ali Sadik,( 2013) “The Extraction and Partial Purification of Wedelolactone from Local Eclipta alba Plant” Iraqi Journal of Science, , Vol 54, Supplement No.4, pp:1084-1089
65. Singh B, Saxena AK, Chandan BK, Agarwal SG, Bhatia MS, Anand KK. (1993 ), Hepatoprotective effect of ethanolic extract of Eclipta alba on experimental liver damage in rats and mice. Phytother Res, Mar 1; 7(2): 154-8.
66. Samudram P., Rajeshwari Hari, Vasuki R., Geetha A. and Sathiya moorthi P.(2008), “Hepatoprotective activity of Bi - herbal ethanolic extract on CCl4 induced hepatic damage in rats” African Journal of Biochemistry Research Vol.2 (2), pp. 061-065.
67. Lal V.K, Amit Kumar, Prashant Kumar, Kuldeep Singh Yadav,( 2010), “Screening of Leaves and Roots of Eclipta alba for Hepatoprotective Activity”, Arch. Appl. Sci. Res; 2(1): 86-94.
68. K. Sateesh naik, M. Gurushanthaiah , M. Kavimani , K. Prabhu , S. Lokanadham, (2018) “Hepatoprotective Role of Eclipta alba against High Fatty Diet Treated Experimental Models – A Histopathological Study” MAEDICA – a Journal of Clinical Medicine, 13(3): 217-222.
69. Banji O, Banji D, Annamalai AR, Manavalan R.( 2007), “Investigation on the effect of eclipta alba on animal models of learning and memory.” Indian J Physiol Pharmacol. Jul-Sep;51(3):274-8.
70. Jayathirtha, M. G., & Mishra, S. H. (2004). “Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica.” Phytomedicine, 11(4), 361–365.doi:10.1078/0944711041495236
71. Christybapita, D., Divyagnaneswari, M., & Dinakaran Michael, R. (2007). Oral administration of Eclipta alba leaf aqueous extract enhances the non-specific immune responses and disease resistance of Oreochromis mossambicus. Fish & Shellfish Immunology, 23(4), 840–852.doi:10.1016/j.fsi.2007.03.010
72. Archna A., Vidya shree H.M., Dr. Ravindra R,(2018), “Effect of eclipta alba adminstration on chronic stress induced behavioral changes in wistar rat” European Journal Of Biomedical And Pharmaceutical Sciences, 5(2), 633-639.
73. Mishra Swati, Jena Monalisa, Pal Abhishek (2013), “Evaluation of antidepressant activity of Eclipta alba using animal models” Asian Journal of Pharmaceutical and Clinical Research.6(3) 118-120.
74. Monalisa, J., Swati, M.S., Pal, A., & Mishra, B.V. (2014). “Memory Enhancing Activity of Eclipta Alba in Albino Rats : A Correlation with Anticholinesterase Activity” International Journal of Pharmaceutical and Clinical Research; 6(2): 179-185
75. Datta K, Singh AT, Mukherjee A, Bhat B, Ramesh B and Burman AC (2009), “ Eclipta alba extract with potential for hair growth promoting activity”. J Ethnopharmacol 124: 450-456.
76. ShahNaz Begum , Mi Ra Lee , Li Juan Gu , Jamil Hossain, Chang Keun Sung,(2015), “Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-β1 expression in nude mice” International Journal of Molecular Medicine 35: 496-502.
77. Begum, S., Lee, M. R., Gu, L. J., Hossain, M. J., Kim, H. K., & Sung, C. K. (2014). Comparative Hair Restorer Efficacy of Medicinal Herb on Nude (Foxn1nu) Mice. BioMed Research International, 2014, 1–9.doi:10.1155/2014/319795.
78. Roy, R. K., Thakur, M., & Dixit, V. K. (2007). Development and evaluation of polyherbal formulation for hair growth-promoting activity. Journal of Cosmetic Dermatology, 6(2), 108–112. doi:10.1111/j.1473-2165.2007.00305.
79. Jaiswal, N., Bhatia, V., Srivastava, S. P., Srivastava, A. K., & Tamrakar, A. K. (2012), “ Antidiabetic effect of Eclipta alba ssociated with the inhibition of alpha-glucosidase and aldose reductase”. Natural Product Research, 26(24), 2363–2367.doi:10.1080/14786419.2012.662648
80. Singh, B., Saxena, A.K., Chandan, B.K., Agrawal, S.G., & Anand, K.K. (2001). In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves. Indian Journal of Physiology and Pharmacology, 45, 435–441.
81. Ananthi J, Prakasam A, Pugalendi KV.( 2003), “Antihyperglycemic Activity of Eclipta alba Leaf on Alloxan-induced Diabetic Rats” . Yale Journal of Biology and Medicine; 76:97-102.
82. Monali Patel, Ramtej Verma and Pranav Srivastav (2016), “Antioxidant activity of Eclipta alba extract” Journal of Medicinal Plants Studies; 4(5): 92-98.
83. Baldi, A. (2013). EVALUATION OF IN VITRO ANTIOXIDANT ACTIVITY OF ECLIPTA ALBA. Acta Horticulturae, (972), 27–31.doi:10.17660/actahortic.2013.972.3
84. Ramesh, V., Hari, R., Pandian, S., & Arumugam, G. (2011). Antioxidant Activity of Combined Ethanolic Extract of Eclipta alba and Piper longum Linn. Journal of Complementary and Integrative Medicine, 8(1). doi:10.2202/1553-3840.1591.
85. Manoj Kumar Pandey, G.N.Singh, Rajeev Kr Sharma and Sneh Lata,( 2011) “Antibacterial activity of Eclipta alba (L.) Hassk” Journal of Applied Pharmaceutical Science, 01 (07); 104-107.
86. Karunambighai. A., Gayatri Devi. S.,( 2013), “Antibacterial Activity of Roots and Leaves of Eclipta alba” Int J Pharm Pharm Sci, Vol 6, Issue 1, 454-456.
87. Ray, A., Bharali, P., & Konwar, B. K. (2013). Mode of Antibacterial Activity of Eclalbasaponin Isolated from Eclipta alba. Applied Biochemistry and Biotechnology, 171(8), 2003–2019. doi:10.1007/s12010-013-0452-3 .
88. S. Suresh Kumar, T. Sivakumar, M.J.N. Chandrasekar, B. Suresh (2005), “Evaluation of Anti –Inflammatory Activity of Eclipta alba in rats”; Anc Sci Life; 24(3): 112–118.
89. Muthu Kumaran Peraman , P. Ramalingam , and Bapatla JNN Sai,( 2011) “Anti-inflammatory and antimicrobial activities of the extracts of Eclipta alba Leaves” European Journal of Experimental Biology, 1 (2):172-177.
90. Sawant, M., Isaac, J. C., & Narayanan, S. (2004). Analgesic studies on total alkaloids and alcohol extracts of Eclipta alba(Linn.) Hassk. Phytotherapy Research, 18(2), 111–113. doi:10.1002/ptr.1165.
91. Niña Theresa P. Dungca, (2016), Protective effect of the methanolic leaf extract of Eclipta alba (L.) Hassk. (Asteraceae) against gentamicin-induced nephrotoxicity in Sprague Dawley rats, Journal of Ethnopharmacology,
92. Rangineni, V., Sharada, D., & Saxena, S. (2007). Diuretic, Hypotensive, and Hypocholesterolemic Effects of Eclipta alba in Mild Hypertensive Subjects: A Pilot Study. Journal of Medicinal Food, 10(1), 143–148.doi:10.1089/jmf.2006.0000
93. Rakesh C. Verma, Pratap Shankar, Shailendra Dwivedi and Rakesh K. Dixit (2012) , “EFFECTS OF ECLIPTA ALBA AND BOERHAAVIA DIFFUSSA ON NORMAL BLOOD PRESSURE AND HYPERTENSION IN RATS AND THEIR COMPARISON WITH AMLODIPINE ” International Journal of Pharmaceutical Science and Research. Vol. 3(6): 1832-1838
94. Yadav, N. K., Arya, R. K., Dev, K., Sharma, C., Hossain, Z., Meena, S., … Singh, R. K. (2017). Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects. Oxidative Medicine and Cellular Longevity, 2017, 1–18.doi:10.1155/2017/9094641.
95. H. Chaudhary, V. Dhuna, J. Singh, S. S. Kamboj, and S. Seshadri (2011), “Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer potential: an in vitro study,” Journal of Ethnopharmacology, vol. 136, no. 2, pp. 363–367.
96. Chaudhary, H., Jena, P. K., & Seshadri, S. (2013). Evaluation of Hydro-Alcoholic Extract ofEclipta albafor its Multidrug Resistance Reversal Potential: An In Vitro Study. Nutrition and Cancer, 65(5), 775–780.doi:10.1080/01635581.2013.789116 .
97. Chaudhary, H., Jena, P. K., & Seshadri, S. (2014). In Vivo Evaluation of Eclipta alba Extract as Anticancer and Multidrug Resistance Reversal Agent. Nutrition and Cancer, 66(5), 904–913.doi:10.1080/01635581.2014.916324 .
98. Arya, R. K., Singh, A., Yadav, N. K., Cheruvu, S. H., Hossain, Z., Meena, S., … Datta, D. (2015). Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis. Scientific Reports, 5(1). doi:10.1038/srep18457 .
99. Panghal, M., Kaushal, V., & Yadav, J. P. (2011). In vitro antimicrobial activity of ten medicinal plants against clinical isolates of oral cancer cases. Annals of Clinical Microbiology and Antimicrobials, 10(1), 21. doi:10.1186/1476-0711-10-21 .
100. Neha Chauhan, Dolly Singh and R.M.Painpuli (2012), “ Screening of Bioprotective Properties and Phytochemical Analysis of Various Extracts of Eclipta alba Whole Plant” Int J Pharm Pharm Sci 2;4(2); 554-560.
101. Anjali singh, Ayodhya Singh, Vandana Dwivedi (2015) “Screening of Hydro-alcoholic Extract of Eclipta alba for its Anticancerous Efficacy”. International Journal of Science and Research. (3);488-491.
102. Patel, M., Panchal, S., & Patel, J. (2009). Antianaphylactic activity of alcoholic extract of Eclipta alba. Journal of Young Pharmacists, 1(3), 244. doi:10.4103/0975-1483.57072.
103. Dr. Indradev Tripathi, Introduced by Acharya Vishwanath Dwivedi .Raj Nighantu; 1st edi. Chaukhamba Krushnadas Academy; Varanasi. Shatahwadi Varga;89.
104. Prof. Priyavrat Sharma Dravyagun vigyan (Hindi).2nd edition Varanasi; Chaukhamba Bharati Academy 1956, Reprinted 2006, (2);123-126.
105. Dr. Brahmanand Tripathi, Ashtang Hrudayam (Hindi), 1st ed. Delhi; Chaukhamba Sanskrit Pratisthan 2007, (2);1203.
106. Acharya Priyavrat Sharma,Guruprasad Sharma, Kaiydev Nighantu (Hindi), 1st edi. Varanasi, Chaukhamba Orientalia; 637.
107. Chunekar. K. C ,Bhavamishra; BhavaprakashaNighantu, Hindi Vyakhya, Chaukhambha Bharati Academy, Varanasi, 2004. Guduchyadi Varga, P. 429.
108. Kaviraj Ambikadatta Shashtri ,Bhaishajyaratnavali,2nd edi; 19th re-edited.Chaukhamba Sanskrit Sansthan.Varanasi.p.556.
109. Shri.Ba.G. Vaidhya ;Nighantu adarsh,Vol.1, Chaukhamba Bharti Akadami , Varanasi; 2nd edi. Sahdevyadi varg p.764-769.
110. Acharya Vidhyadhar Shukla Prof.RavidattaTripathi Dr.Brahmanand Tripathi, Charak Sanhita (hindi), 1stedi.Delhi;Chaukhamba Sanskrit prasthan ,2007;Vol.1,p-639.
111. Madhav A. editor. Ayurveda Prakasha. Reprint Edition. Ver. 3. Ch. 2. Varanasi : Chaukhamba Bharti Academy ;2007.p.30.
112. Pol H., More S, Vyas MK, Vyas H, Ravishankar B. Fundamental Approach in the management of Drava Bahula Amlapitta with Bhringaraja (Eclipta Alba). AYU 2011;32:512-7.
113. Kaviraj Ambikadatta Shashtri ,Bhaishajyaratnavali,2nd edi; 19th re-edited.Chaukhamba Sanskrit Sansthan: Varanasi. Shirorogadhikara p.49-51.
114. Shailajan S, Menon SN, Tiwari BR, Singh AS. Standardization of Shadbindu Taila: An Ayurvedic oil based medicine. AYU 2013;34:103-7.
115. Srikantha Murthy KR. Bhavaprakasha of Bhavamishra. Vol. 2. Varanasi: Krishnadasa Academy; 2002. p. 680,62/42-48.
116. Shukla (Upadhyay) K, Karunagoda K, Sata N, Dei L. P., “ Effect Of Kumari Tail Uttar Basti on fallopian tube blockage.” AYU 2010; 31:424-9.
117. Chakrapanidatta, Chakradatta . 4th ed. Varanasi: Chaukhambha Sanskrit Series; 2002. Chapter 50-Kushtha Chikitsa, Shloka no-17 edited by Prof. Ramanath Dwivedy; p. 279.
118. Mehta C.S., Dave A.R., Shukla V.D. Comparative effect of Navayasa Rasayana and Medhya Rasayana tablet along with Dhatryadhyo Lepa in Ekkakushta (psoriasis). AYU 2013: 34: 243-8.



I  declare (on behalf of me and my co-authors) that the submitted manuscript titled has not previously been published and is not currently being considered elsewhere for publication in another journal and that I am (we are) the sole owner(s) of the manuscript thereof and of all rights, title, and interest therein. All agreed to the terms and conditions, Privacy Policy, which is declared on Journal Website and online filled (uploaded) form


Download data is not yet available.