Inflammatory Joint Disease in Ayurvedic Medicine


  • Matin Shaikh
  • Medha Kulkarni


Amavata, RA, rheumatoid arthritis, vatavyadhi


Amavata is a disease of chronic joint and body pain, accompanied by a swelling of some or all of the synovial joints. These symptoms are typically accompanied by immobility, a loss of taste, thirst, indigestion, a lack of enthusiasm, a feeling of heaviness, and fever. If the condition is allowed to progress the pains may begin to migrate from place to place, with an intense stinging and/or burning sensation. There may be scanty, frequent urination, and sleep may become disturbed. The digestion will continue to worsen, with bowel irritability and spasm, constipation, nausea, and vomiting. 

Amavata displays many features in common with a collection of signs and symptoms that are typically diagnosed as rheumatoid arthritis (RA). The cause of RA is still the subject of some contention among pathologists, but most theories to date either advocate an autoimmune mechanism or an infectious agent. In conventional medicine RA is typically treated with non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, immunosuppressive drugs Despite the obvious similarities between it and RA, amavata is nonetheless very different. It is a distinct etiological and pathological model, based on the interaction and influence of the three doshas, vis. Vata, Pitta and Kapha. Thus, the treatment regimen for amavata has entirely different objectives than those of RA, and very likely different results. Amavata may also include the features of other conditions, from the more pedestrian diagnoses such as arthritis, to more ‘exotic’ conditions such as ankylosing spondylitis.


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1. Abdul-Ghani AS, Amin R. 1997. Effect of aqueous extract of Commiphora opobalsamum on blood pressure and heart rate in rats. J Ethnopharmacol 1997 Aug;57(3):219-22
2. al-Harbi MM, Qureshi S, Raza M, Ahmed MM, Afzal M, Shah AH. 1997. Gastric antiulcer and cytoprotective effect of Commiphora molmol in rats. J EthnopharmacolJan;55(2):141-50
3. al-Hindawi, M.K., S.H. Al-Khafaji, and M.H. Abdul-Nabi. 1992, Anti-granuloma activity of Iraqi Withania somnifera. J Ethnopharmacol. Sep; 37(2):113-6
4. al-Hindawi, M.K., I.H. Al-Deen, M.H. Nabi, and M.H. Ismail. 1989. Anti-inflammatory activity of some Iraqi plants using intact rats. J Ethnopharmacol. Sep; 26(2):163-8
5. Andersson M, Bergendorff O, Shan R, Zygmunt P, Sterner O. 1997. Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti). Planta Med Jun;63(3):251-4
6. Andallu B, Radhika B. 2000. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root.Indian J Exp Biol Jun;38(6):607-9
7. Archana, R. and A. Namasivayam. 1999. Antistressor effect of Withania somnifera. J Ethnopharmacol. Jan; 64(1):91-3
8. Berkow, Robert ed. et al. 1992. The Merck Manual of Diagnosis and Therapy. 17th ed. Rahway, NJ: Merck and Co.
9. Bhatt AD, Dalal DG, Shah SJ, Joshi BA, Gajjar MN, Vaidya RA, Vaidya AB, Antarkar DS. 1995. Conceptual and methodologic challenges of assessing the short-term efficacy of Guggulu in obesity: data emergent from a naturalistic clinical trial. .J Postgrad MedJan-Mar;41(1):5-7
10. Bhattacharya, S.K., K.S. Satyan and S. Ghosal. 1997. Antioxidant activity of glycowithanolides from Withania somnifera. Indian J Exp Biol. Mar; 35(3):236-9
11. Bhattacharya SK, Maity PC, Mediratta P, Sen P. 1991. Modulation of humoral immune responses by Tinospora malabarica in experimental animals. Indian J Exp BiolOct;29(10):971-2
12. Creencia, E., T. Eguchi, T. Nishimura, and K. Kakinuma. 1996. Isolation and Structure Elucidation of the Biologically Active Components of Terminalia chebula Retzius (Combretaceae). KIMIKA 12:1-10
13. Dash, Bhagwan. 1991. Materia Medica of Ayurveda. New Delhi: B. Jain Publishers.
14. Dash, Bhagwan and Manfred Junius. 1983. A Handbook of Ayurveda. New Delhi: Concept Publishing.
15. Davis L. and G. Kuttan. 1998. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol. Oct; 62(3):209-14
16. Devi, P.U. 1996. Withania somnifera Dunal (Ashwagandha): potential plant source of a promising drug for cancer chemotherapy and radiosensitization. Indian J Exp Biol.Oct; 34(10):927-32
17. Dhuley, J.N. 1998. Effect of Ashwagandha on lipid peroxidation in stress-induced animals. J Ethnopharmacol. Mar; 60(2):173-8
18. Dutta, B.K., I. Rahman, and T.K. Das. 1998. Antifungal activity of Indian plant extracts. Mycoses. Dec; 41(11-12):535-6
19. el-Mekkawy, S et al. 1995. Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase. Chem Pharm Bull Apr; 43(4):641-8
20. Galland, Leo. 1995. Leaky Gut Syndromes: Breaking the Vicious Cycle. Towsend Letter for Doctors. Aug/Sep: 62-68
21. India. Ministry of Health and Family Planning. 1978. The Ayurvedic Formulary of India. Part 1. 1 ed. Delhi
22. Kirtikar KR and BD Basu. 1935. Indian Medicinal Plants. 2 ed. Vol. 1-4. Reprinted in 1993. Delhi: Periodical Experts.
23. Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. 1991. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. May-Jun;33(1-2):91-5
24. Kulkarni, S.K. and I. Ninan. 1997. Inhibition of morphine tolerance and dependence by Withania somnifera in mice. J Ethnopharmacol. Aug; 57(3):213-7
25. Lata S, Saxena KK, Bhasin V, Saxena RS, Kumar A, Srivastava VK. 1991 Beneficial effects of Allium sativum, Allium cepa and Commiphora mukul on experimental hyperlipidemia and atherosclerosis - a comparative evaluation. J Postgrad MedJul;37(3):132-5
26. Matthai TP, Date A. 1979. Renal cortical necrosis following exposure to sap of the marking-nut tree (Semecarpus anacardium). Am J Trop Med Hyg Jul;28(4):773-4
27. Mehta, A.K., P. Binkley, S.S. Gandhi, and M.K. Ticku. 1991. Pharmacological effects of Withania somnifera root extract on GABAA receptor complex. Indian J Med Res. Aug; 94:312-5
28. Mills, Simon and Kerry Bone. 2000. Principles and Practice of Phytotherapy.London: Churchill Livingstone
29. Nadkarni, K.M. and A.K. Nadkarni. 1954. Indian Materia Medica. Vol 1. 3 rev. Mumbai (Bombay): Popular Prakashan Private Ltd.
30. Najib Nik A Rahman N, Furuta T, Kojima S, Takane K, Ali Mohd M. 1999. Antimalarial activity of extracts of Malaysian medicinal plants. J EthnopharmacolMar;64(3):249-54
31. Nityanand S, Srivastava JS, Asthana OP. 1989. Clinical trials with gugulipid. A new hypolipidaemic agent. J Assoc Physicians India. May;37(5):323-8
32. Phadke, S.A., and S.D. Kulkarni. 1989. Screening of in vitro antibacterial activity of Terminalia chebula, Eclipta alba and Ocimum sanctum. Indian J Med Sci. May; 43(5):113-7
33. Premalatha B, Sachdanandam P. 2000. Potency of Semecarpus anacardium Linn. nut milk extract against aflatoxin B(1)-induced hepatocarcinogenesis: reflection on microsomal biotransformation enzymes. Pharmacol Res Aug;42(2):161-6
34. Premalatha B, Sachdanandam P. 1999. Semecarpus anacardium L. nut extract administration induces the in vivo antioxidant defence system in aflatoxin B1 mediated hepatocellular carcinoma. J Ethnopharmacol Aug;66(2):131-9
35. Prince PS, Menon VP. 1999. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes J Ethnopharmacol 1999 Jun;65(3):277-81
36. Qureshi S, al-Harbi MM, Ahmed MM, Raza M, Giangreco AB, Shah AH. 1993. Evaluation of the genotoxic, cytotoxic, and antitumor properties of Commiphora molmol using normal and Ehrlich ascites carcinoma cell-bearing Swiss albino mice. Cancer Chemother Pharmacol 33(2):130-8
37. Rege NN et al. 1999. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res Jun;13(4):275-91
38. Rege N, Bapat RD, Koti R, Desai NK, Dahanukar S. 1993. Immunotherapy with Tinospora cordifolia: a new lead in the management of obstructive jaundice. Indian J Gastroenterol Jan;12(1):5-8
39. Sarbhoy AK, Varshney JL, Maheshwari ML, Saxena DB. 1978. Efficacy of some essential oils and their constituents on few ubiquitous molds. Zentralbl Bakteriol[Naturwiss] 1978;133(7-8):723-5
40. Sharma A, Mathur R, Dixit VP. 1995. Hypocholesterolemic activity of nut shell extract of Semecarpus anacardium (Bhilawa) in cholesterol fed rabbits. Indian J Exp BiolJun;33(6):444-8
41. Sharma, P.V. 2002. Cakradatta (Sanskrit text with English translation). 3 ed. Varanasi: Chaukhamba Orientalia.
42. Shukla SD, Jain S, Sharma K, Bhatnagar M. 2000. Stress induced neuron degeneration and protective effects of Semecarpus anacardium Linn. and Withania somnifera Dunn. in hippocampus of albino rats: an ultrastructural study. Indian J Exp Biol 2000 Oct;38(10):1007-13
43. Singh RB, Niaz MA, Ghosh S. 1994. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther 1994 Aug;8(4):659-64
44. Sohni, Y.R., P. Kaimal, and R.M. Bhatt. 1995. The antiamoebic effect of a crude drug formulation of herbal extracts against Entamoeba histolytica in vitro and in vivo. J Ethnopharmacol. Jan; 45(1):43-52
45. Smit HF, Woerdenbag HJ, Singh RH, Meulenbeld GJ, Labadie RP, Zwaving JH. 1995. Ayurvedic herbal drugs with possible cytostatic activity. J Ethnopharmacol Jul 7;47(2):75-84
46. Srikantha Murthy K.R. 1996. Madhava Nidanam (Roga Viniscaya of Madhavakara). 2 ed. Varanasi: Chaukhamba Orientalia.1994.
47. Vagbhata’s Ashtanga Hrdayam. Vol 1. Varanasi: Krishnadas Academy
48. Prince P, Menon VP, Gunasekaran G. Stanely Mainzen. 1999. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J Ethnopharmacol. Jan;64(1):53-7
49. Tariq M, Ageel AM, Al-Yahya MA, Mossa JS, Al-Said MS, Parmar NS. 1986. Anti-inflammatory activity of Commiphora molmol. Agents Actions 17(3-4):381-2
50. Thakur, C.P., B. Thakur, S. Singh, P.K. Sinha, and S.K. Sinha. 1988. The Ayurvedic medicines Haritaki, Amala and Bahira reduce cholesterol-induced atherosclerosis in rabbits. Int J Cardiol. Nov; 21(2):167-75.
51. Thatte UM, Rao SG, Dahanukar SA. 1994. Tinospora cordifolia induces colony stimulating activity in serum. J Postgrad Med. Oct-Dec;40(4):202-3
52. Tripathi YB, Malhotra OP, Tripathi SN. 1984. Thyroid stimulating action of Z-guggulsterone obtained from Commiphora mukul. Planta Med Feb;(1):78-80
53. Varier, V.P.S. 1996. Indian Medicinal Plants: A Compendium of 500 species. Edited by PK Warrier, VPK Nambiar and C Ramankutty. vol 5. Hyderabad: Orient Longman.
54. Indian Medicinal Plants: A Compendium of 500 species. Edited by PK Warrier, VPK Nambiar and C Ramankutty. vol 4. Hyderabad: Orient Longman, 1995b.
55. 1995a. Indian Medicinal Plants: A Compendium of 500 species. Edited by PK Warrier, VPK Nambiar and C Ramankutty. vol 3. Hyderabad: Orient Longman.
56. Indian Medicinal Plants: A Compendium of 500 species. Edited by PK Warrier, VPK Nambiar and C Ramankutty. vol 2. Hyderabad: Orient Longman, 1994b.
57. Indian Medicinal Plants: A Compendium of 500 species. Edited by PK Warrier, VPK Nambiar and C Ramankutty. vol 1. Hyderabad: Orient Longman, 1994a.
58. Vijayalakshmi T, Muthulakshmi V, Sachdanandam P. 2000. Toxic studies on biochemical parameters carried out in rats with Serankottai nei, a siddha drug-milk extract of Semecarpus anacardium nut. J Ethnopharmacol. Jan;69(1):9-15
59. Vijayalakshmi T, Muthulakshmi V, Sachdanandam P. 1997. Effect of milk extract of Semecarpus anacardium nuts on glycohydrolases and lysosomal stability in adjuvant arthritis in rats. J Ethnopharmacol Sep;58(1):1-8
60. Ziauddin, M., N. Phansalkar, P. Patki , S. Diwanay, B. Patwardhan. 1996. Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol. Feb; 50(2):69-76



How to Cite

Shaikh, M., & Kulkarni, M. (2019). Inflammatory Joint Disease in Ayurvedic Medicine. Ayurline: International Journal of Research in Indian Medicine, 3(01). Retrieved from