Background: Mutrashmari (urinary stones) is one among the ashtamahagada (eight fatal conditions) and is kaphapradhan tridoshaja vyadhi, which can be correlated with nephrolithiasis. The recurrence rate is 50 to 80%. Males are more frequently affected than the female and their ratio is 4:3. The incidence is still higher in the age group between 30-45 years. Many treatment modalities have been adopted in medical sciences, but it is quite expensive and also the pathogenesis behind recurrence of formation of stone cannot be avoided. Hence, it is necessary to find out an economical effective, easily available medicine to treat mutrashmari. Objectives: The aim of this study was to evaluate the efficacy of panchakarma like virechana, yogabasti and shamana chikitsa in mutrashmari w.r.t. to nephrolithiasis. Materials and Methods: In this case series 3 patients with complaints of pain in abdomen and back, which was radiating from loin to groin region; burning micturition; and dysuria were diagnosed as nephrolithiasis and treated. The patients were administered with panchakarma like virechana, yogabasti and shaman aushadhi. Results: The patient got significant results in chief and associated complaints. Conclusion: Satisfactory relief in symptoms were seen in patient of nephrolithiasis by ayurvedic management and there was no recurrence.
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