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Ayurveda is an ancient medical science which main aim is to maintain the health of a healthy person and cure diseases from its root. Ayurved is based on Saptapadartha, where dravya is one of them. Ancient Acharyas classified the Ayurveda into eight branches, collectively known as “Ashtang Ayurveda”. Dravyaguna Shastra is an important branch of chikitsa shastra. This deals with the guna (properties), karma (action), and Prayoganum (therapeutic uses of dravya). In Ayurveda “Ekal dravya” chikitsa having more importance. In some context, a single drug (Ekal Dravya) is used for one disease or more than one disease. Agrya Aushadhi Dravya is the most potent drug for that particular disease. Agrya Aushadhi Dravya is cost-effective economical, easy to use, and safe. This article highlighting the Agrya Aushadhi dravya mentioned in a charak samhita which acting on different body systems.