Evaluate To Evaluate the effect of Marich (Piper nigrum., Linn.) on experimental model of high fat diet induced Hyperlipidemia .

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Abstract

Ayurveda conceives and describes the basic and applied aspects and principles of life process,, health and diseases and its management in terms of its own principles and approaches. Because of luxurious life and sedentary habits body fats along with cholesterols are increasing in the body, which invites the disorders like hypertension, heart diseases, and hyperlipidemia. Hyperlipidemia is a condition in which the levels of lipoproteins, i.e cholesterols, triglycerides or both are raided in plasma to the extent that it may have adverse effect in health leading to life expectancy. The experimental study was carried out for 42 days. In which for first 2ldays the obesity was induced by creating high fat induced obesity experimental model of wistar rats male ,which was further treated for next 21 days with three different test drug doseage  of Marich (A), of 90mg/kg., Marich (B) of 180mg/kg and Marich (C) of 270mg/kg were used. For obesity induction Vanaspati Ghee (Dalda) and coconut oil (Parachute) was used in which daily pellets were soaked overnight .The Lipids were recorded , the blood samples were collected on 0, 21 and 42 days respectilvely .Standard Drug Atorvastatin was used . The blood samples were send for histopathological results and the stastistical analysis was done with Annova method. Obesity was induced till day'21 and again was reduced satisfactorly by Marich group(A) and group (C ) showed maximum satisfactory results with histopathological changes.